11/20/2023 0 Comments Hippocampus mythology brain![]() ![]() ![]() However, source reconstruction of the EEG is complicated by the fact that electrical signals are vulnerable to distortions by skull, skin, and cerebrospinal fluid (CSF) ( Nunez and Srinavasan, 2006 Lopes da Silva, 2010 Cohen, 2017). The scalp electroencephalogram (EEG) provides high temporal resolution on a timescale of milliseconds. fMRI is frequently used in experimental studies of hippocampal activation in healthy humans however due to its limited temporal resolution ( Buckner and Logan, 2001), the frequency specificity and time course of rhythmic neuronal activity cannot be resolved with this technique. At the present time, there are several different methods available to investigate the function of the human hippocampus. Neuronal oscillations are believed to be important mechanisms for these processes ( Colgin, 2016) and it is thus of great importance to understand the functions of hippocampal rhythms. The hippocampus is an important brain region for various cognitive processes, including spatial navigation ( O'Keefe and Nadel, 1978 Buzsaki and Moser, 2013), memory ( Horner and Doeller, 2017), and language comprehension ( Piai et al., 2016). Overall, these studies confirm that MEG provides a unique avenue to investigate human hippocampal rhythms in cognition, and can bridge the gap between animal studies and human hippocampal research, as well as elucidate the functional role and the behavioral correlates of human hippocampal oscillations. This paper systematically reviews simulation studies and empirical evidence of the current capacities and limitations of MEG “deep source imaging” of the human hippocampus. However, with the advent of whole-head MEG systems in the 1990s and development of advanced source localization techniques, simulation and empirical studies have provided evidence that human hippocampal signals can be sensed by MEG and reliably reconstructed by source localization algorithms. Due to the location of the hippocampus deep in the brain, studying hippocampal rhythms using non-invasive magnetoencephalography (MEG) recordings has generally been assumed to be methodologically challenging. Hippocampal rhythms are believed to support crucial cognitive processes including memory, navigation, and language. 5Brain and Psychological Sciences Research Centre, Swinburne University of Technology, Melbourne, VIC, Australia.4Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.3Program in Neurosciences and Mental Health, Hospital for Sick Children Research Institute, Toronto, ON, Canada.2Department of Cognitive Science, Macquarie University, Sydney, NSW, Australia.1ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, NSW, Australia. ![]()
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